NEXT GENERATION BIOPHYSICS 2019

Next Generation Biophysics 2019

An informal one day meeting organised by Astra Zeneca, MRC LMB and Imperial College London examining the application of cutting edge biophysical techniques in complex biological settings. Bringing together scientists in both academia and industry for stimulating talks and discussions how these new and emerging technologies may be able to address challenging questions in the future.

To register for the Meeting, please follow the  link. 

PROGRAMME

9:25      Welcome/Introduction by Mike Snowden, Head of Discovery Sciences, AstraZeneca

 

Session I – New and Emerging Technologies   Chair: Christopher Johnson. MRC-LMB, Cambridge

9:30      Christopher Russo.  MRC LMB, Cambridge.

               Understanding and approaching some physical limits in CryoEM

10:00    Paul French.  Imperial College London.

              Multidimensional fluorescence imaging

10:30    Madhavi Krishnan.  Chemistry, Oxford.

              Bringing electrostatics to light: Electrometry probes a new dimension at the molecular scale

11:00    Coffee Break

 

 Session II – Molecular Conformation and Architecture Chair: Stephen McLaughlin. MRC LMB, Cambridge

11:30    Alireza Mashaghi-Tabari.  Leiden University, Netherlands

             Dissecting cellular protein folding processes using single-molecule force spectroscopy

12:00    Peter St George-Hyslop, Cambridge Institute for Medical Research

             Physiological and Pathological Biological Condensates in Neurons

12:30    Wanda Kukulski. MRC LMB, Cambridge.

             Using correlative microscopy and electron cryo-tomography to visualise the molecular architecture of cellular membranes

1:00      Lunch Break

 

Session III – Single Molecule Applications Chair: David Rueda. Imperial College London

2:00      Stephan Uphoff. Biochemistry, Oxford.

              Single-molecule imaging of bacterial DNA repair and mutagenesis

2:30      Anders Gunnarsson. AstraZeneca

              Small-molecule drug discovery enabled through dynamic and static single-molecule detection approaches

3:00      Christian Speck. Imperial College London.

              Structural and functional analysis of eukaryotic DNA replication

3:30      Coffee Break

 

Session IV – Molecular Mass Matters.  Chair: Maria Flocco, Astra Zeneca

4:00      Justin Benesch. Chemistry, Oxford.

            Weighing the evidence for protein structure and dynamics

4:30      Jonathan Wingfield.   AstraZeneca

            Mass spectrometry at the speed of sound: the application of acoustics for sample loading

 

Keynote Lecture

5:00      Prof Dame Carol Robinson. Chemistry, Oxford.

From peripheral proteins to membrane motors – mass spectrometry comes of age  

 

5:45      Close of Meeting by Jan Lowe, Director of the MRC LMB

 

ORGANISERS:

Chris Johnson, MRC Laboratory of Molecular Biology,

Stephen McLaughlin, MRC Laboratory of Molecular Biology,

David Rueda, Department of Medicine, Imperial College London,

Maria Flocco, AstraZeneca UK,

Geoff Holdgate, AstraZeneca UK.