An informal one day meeting organised by Astra Zeneca, MRC LMB and Imperial College London examining the application of cutting edge biophysical techniques in complex biological settings. Bringing together scientists in both academia and industry for stimulating talks and discussions how these new and emerging technologies may be able to address challenging questions in the future.
To register for the Meeting, please follow the link.
9:25 Welcome/Introduction by Mike Snowden, Head of Discovery Sciences, AstraZeneca
Session I – New and Emerging Technologies Chair: Christopher Johnson. MRC-LMB, Cambridge
9:30 Christopher Russo. MRC LMB, Cambridge.
Understanding and approaching some physical limits in CryoEM
10:00 Paul French. Imperial College London.
Multidimensional fluorescence imaging
10:30 Madhavi Krishnan. Chemistry, Oxford.
Bringing electrostatics to light: Electrometry probes a new dimension at the molecular scale
11:00 Coffee Break
Session II – Molecular Conformation and Architecture Chair: Stephen McLaughlin. MRC LMB, Cambridge
11:30 Alireza Mashaghi-Tabari. Leiden University, Netherlands
Dissecting cellular protein folding processes using single-molecule force spectroscopy
12:00 Peter St George-Hyslop, Cambridge Institute for Medical Research
Physiological and Pathological Biological Condensates in Neurons
12:30 Wanda Kukulski. MRC LMB, Cambridge.
Using correlative microscopy and electron cryo-tomography to visualise the molecular architecture of cellular membranes
1:00 Lunch Break
Session III – Single Molecule Applications Chair: David Rueda. Imperial College London
2:00 Stephan Uphoff. Biochemistry, Oxford.
Single-molecule imaging of bacterial DNA repair and mutagenesis
2:30 Anders Gunnarsson. AstraZeneca
Small-molecule drug discovery enabled through dynamic and static single-molecule detection approaches
3:00 Christian Speck. Imperial College London.
Structural and functional analysis of eukaryotic DNA replication
3:30 Coffee Break
Session IV – Molecular Mass Matters. Chair: Maria Flocco, Astra Zeneca
4:00 Justin Benesch. Chemistry, Oxford.
Weighing the evidence for protein structure and dynamics
4:30 Jonathan Wingfield. AstraZeneca
Mass spectrometry at the speed of sound: the application of acoustics for sample loading
5:00 Prof Dame Carol Robinson. Chemistry, Oxford.
From peripheral proteins to membrane motors – mass spectrometry comes of age
5:45 Close of Meeting by Jan Lowe, Director of the MRC LMB
Chris Johnson, MRC Laboratory of Molecular Biology,
Stephen McLaughlin, MRC Laboratory of Molecular Biology,
David Rueda, Department of Medicine, Imperial College London,
Maria Flocco, AstraZeneca UK,
Geoff Holdgate, AstraZeneca UK.