An informal one day virtual meeting (Wednesday, 7th October 2020) organised by Astra Zeneca, MRC LMB and Imperial College London examining the application of cutting edge biophysical techniques in complex biological settings. Bringing together scientists in both academia and industry for stimulating talks and discussions how these new and emerging technologies may be able to address challenging questions in the future.
11.00-12.25: Session I: Imaging Across Scales
Andrew Carter. MRC Laboratory of Molecular Biology, UK.
Shulin: a novel factor packaging axonemal outer dynein arms for ciliary targeting
Julia Mahamid. EMBL Heidelberg, Germany.
Molecular view into cellular functions by in-cell cryo-electron tomography
Richard Goodwin. Drug Discovery AstraZeneca, UK.
Integrated molecular imaging–technologies with the power to offer a new view on the tissue microenvironment and map the efficacy and safety of new therapies
13.00-14.15: Session II: Theory and Simulation
Philip Biggin. Dept. Biochemistry, University of Oxford, UK. Computational biophysics of trafficking receptors
Martin Depken. TU Delft, Netherlands.
Using mechanistic modelling to improve off-target activity predictions and elucidate the physical basis of SpCas9 fidelity
Jean-Philip Piquemal. Dept. Chemistry, Sorbonne University, France. TBC
14.30-15.45: Session III: Biological Phase Separation
Evan Sprujit. Radboud University, Netherlands.
Understanding biological phase transitions with minimal peptide-based models
Priya Banerjee. Dept. Physics. University at Buffalo, USA.
Emergent structure and dynamics of protein-RNA condensates
Stephanie Weber. Dept. Biology, McGill University, Canada.
No membrane, no problem: condensing bacterial organelles
16.00-17.00 Keynote Lecture
Petra Schwille. Director, Max Plank Institute for Biochemistry, Martinsried, Germany.
Is there a minimal set of functions for life?