Day 1: March 19, 2018 (Monday)

13:30 - 14:00 Welcome and Introduction (Lecture Hall)

14:00 - 14:35 Keynote lecture

AFM DIFFERENTIATION BETWEEN NORMAL AND CANCER CELLS AT SINGLE CELL AND MOLECULE LEVELS. Małgorzata Lekka, Krakow, PL

14:35 - 15:50 Nanomechanics, from virus to cell-based diagnosis (1)

14:35 - 14:55 MECHANICAL STIFFNESS, CAPSID DYNAMICS AND VIRAL IINFECTIVITY. Alejandro Valbuena, Madrid, ES

14:55 - 15:15 ALGAL CELL NANNOMECHANICAL PROPERTIES AND ADHESION DYNAMICS AT THE MODEL INTERFACE. Nadica Ivosevic DeNardis, Zagreb, HR

15:15 - 15:35 FIBRINOGEN-INDUCED ERYTHROCYTE-ERYTHROCYTE ADHESION RELEVANCE AS CARDIOVASCULAR RISK FACTOR. Ana F. Guedes, Lisboa, PT

15:35 - 15:50 Company presentation: Oxford Nanoimaging

15:50 - 16:20 Coffee break

16:20 - 18:00 Nanomechanics, from virus to cell-based diagnosis (2)

16:20 - 16:40 AFM/QCM-D METHODS IN THE DIAGNOSTICS AND PROGNOSTICS OF MALIGNANT MELANOMA. Anna Sobiepanek, Warsaw, PL

16:40 - 17:00 AFM COMBINED WITH MASS SPECTROMETRY AS A TOOL FOR COMPLEX ANALYSIS OF SINGLE CANCEROUS CELLS. Justyna Bobrowska, Krakow, PL

17:00 - 17:20 PROBING OF EXTRA-CELLULAR VESICLES BY ATOMIC FORCE MICROSCOPY. Wouter Roos, Groningen, NL

17:20 - 18:00 Flash presentations from STSM laureates

1. Adela Štimac. Zagreb, HR
2. Benjamin Dudenhoeffer. Bayreuth, GE
3. Kairi Kivirand. Tartu, EE
4. Antonio Quintana. Sevilla, ES
5. Ria Katalin Balogh. Szeged, HU (represented by Béla Gyurcsik)
6. Christophe Cullin. Bordeaux, FR (represented by Isabel Alves)
7. Li Peng Lundgren. Copenhagen, DK (represented by Blanca Lopez-Mendez)
8. Zoe Stroud. Birmingham, UK (represented by Bertrand Raynal)

18:00 - 20:00 Poster session 1 (Exhibition Hall)

 

Day 2: March 20, 2018 (Tuesday)

9:00 - 9:35 Keynote lecture

ROLE OF FLUCTUATIONS FOR DRIVING BIOMACHINES. Toshio Yanagida, Osaka, JP

9:35 - 10:50 Combining Biophysical Methods

9:35 - 9:55 EXPERIMENTAL INVESTIGATION OF THE EFFECTS OF MACROMOLECULAR CROWDING ON PROTEIN CONFORMATION. Josef Hamacek, Orleans, FR

9:55 - 10:15 BIOPHYSICAL CHARACTERIZATION OF ALGINATES: A MULTITOOL APPROACH. Bjorn Stokke. Trondheim, NO

10:15 - 10:35 HYDENGE: A PROGRAM FOR AB INITIO SHAPE DETERMINATION USING YDRODYNAMIC PARAMETERS ACQUIRED ON BENCHTOP BIOPHYSICAL INSTRUMENTS. Bertrand Raynal, Paris, FR

10:35 - 10:50 Company presentation: Beckman-Coulter

10:50 - 11:20 Coffee break

11:20 - 12:00 Intrinsically Disordered Proteins

11:20 - 11:40 ROLE OF INTRINSIC DISORDER IN THE PROTEIN NETWORK FOR ACTIVATION OF NICKEL-DEPENDENT UREASE. Barbara Zambelli, Bologna, IT

11:40 - 12:00 EXPERIMENTAL MOLECULAR SCREENING FOR IDENTIFYING PHARMACOCHAPERONES AND INHIBITORS AGAINST INTRINSICALLY DISORDERED PROTEINS. Adrian Velazquez-Campoy, Zaragoza, ES

12:00 - 12:30 Flash presentations 1: Protein Structure, Interactions & Function

1. INTRINSIC PROTEIN DISORDER COULD BE OVERLOOKED IN COCRYSTALLIZATION CONDITIONS: AN SRCD CASE-STUDY. Béla Gyurcsik, Szeged, HU
2. CYTOCHROME C OXIDASE – A KEY COMPONENT OF THE OXIDATIVE PHOSPHORYLATION: REGULATION OF ITS CATALYTIC ACTIVITY. Daniel Jancura, Kosice, SK
3. REDOX SIGNALLING: INTERACTIONS OF SULFIREDOXIN WITH DECAMERIC PEROXIREDOXIN. Hortense Mazon, Nancy, FR
4. SPECTRAL ANALYSIS AND STRUCTURAL MODELING OF CYTOCHROME b561 PROTEINS. László Zimányi, Szeged, HU
5. PROTEIN-PROTEIN AND PROTEIN-DNA INTERACTIONS BY SWITCHSENSE: COMPARISON WITH OTHER APPROACHES. Paloma Fernández Varela, Paris, FR
6. MECHANISM OF MICROTUBULE PAIR SLIDING DRIVEN BY KINESIN-1. Beata Kliszcz, Warsaw, PL

12:30 - 13:30 Lunch

13:30 - 14:05 Keynote lecture

FOLDING AND BINDING LANDSCAPES OF GQUADRUPLEX DNA STRUCTURES. Jonathan B. Chaires, Louisville, USA

14:05 - 15:00 Macromolecular Structure & Interactions (1)

14:05 - 14:25 DEVELOPMENT OF AN INFRARED SPECTROSCOPY DATA REPOSITORY. Erik Goormaghtigh, Brussels, BE

14:25 - 14:45 EXTRACELLULAR INTERACTION NETWORKS: FROM STRUCTURE TO FUNCTIONS. Sylvie Ricard-Blum, Lyon, FR

14:45 - 15:00 Company presentation: Nanotemper

15:00 - 15:30 Coffee break

15:30 - 16:30 Macromolecular Structure & Interactions (2)

15:30 - 15:50 CHARACTERIZING THE INTERACTION BETWEEN TAU AND MICROTUBULES USING SITE-DIRECTED SPIN LABELING EPR SPECTROSCOPY. Marlène Martinho, Marseille, FR

15:50 - 16:10 THE C-TERMINAL EXTENSION OF MAGI-1 PDZ 2/6 IN THE BOUND STATE: RESTRAINING THE CONFORMATIONAL SPACE USING PARAMAGNETIC RELAXATION ENHANCEMENT EFFECT. Yves Nominé, Strasbourg, FR

16:10 - 16:30 mRNA FATE IS CONTROLLED BY HIGHLY REGULATED RNA-BINDING PROTEINS. Irene Díaz-Moreno, Sevilla, ES

16:30 - 17:00 Flash presentations 2: Cell Mechanics & Miscellaneous

1. REVEALING DYNAMIC ALPHA-HELICAL POLYMERS OF KFRR751 PLASMIDIC PROTEIN AND MAPPING OF ITS DNA- BINDING DOMAIN VIA BIOPHYSICAL MEASUREMENTS. Malgorzata Adamczyk, Warsaw, PL
2. THE PORE ARCHITECTURE FORMED BY TWO CHOLESTEROL DEPENDENT CYTOLYSINS IS TUNED BY THE MEMBRANE LIPID COMPOSITION. Mauro Dalla Serra, Trento, IT
3. ROLE OF MARINE GEL IN SCAVENGING AND STABILIZING SILICA NANOPARTICLES IN THE MARINE ENVIRONMENT. Tea Mišić Radić, Zagreb, HR
4. NON-CONTACT MECHANICAL AND CHEMICAL ANALYSIS OF SINGLE LIVING CELLS BY MICROSPECTROSCOPIC TECHNIQUES. Silvia Caponi, Perugia, IT
5. USING AFM TO STUDY ERYTHROCYTES’ MORPHOLOGY AND ELASTICITY ON AMYOTROPHIC LATERAL SCLEROSIS. Catarina S.Lopes, Lisboa, PT
6. AFM ANALYSIS OF P-CADHERIN/SFK MECHANOTRANSDUCTION SIGNALLING IN BREAST CANCER CELLS. Nuno C. Santos, Lisboa, PT

17:00 - 17:15 Company presentation: Fluidic Analytics

17:15 - 17:45 Coffee break

17:45 - 19:30 Poster session 2 (Exhibition Hall)

17:40 - 19:30 Full Management Committee Meeting (room 012)

 

Day 3: March 21, 2018 (Wednesday)

9:00 - 9:35 Keynote lecture

SOLUBILISATION OF MEMBRANE PROTEINS INTO UNCTIONAL LIPID-BILAYER NANODISCS USING AMPHIPHILIC COPOLYMERS. Sandro Keller, Kaiserslautern, DE

9:35 - 10:35 Membranes & Extracellular Vesicles

9:35 - 9:55 IMPACT OF MEMBRANE LIPID COMPOSITION ON DOPAMINE D2 RECEPTOR ACTIVATION. Isabel Alves, Bordeaux, FR

9:55 - 10:15 CONTROLLING THE DIFFUSION OF SUPPORTED LIPID BILAYERS AS CELL MEMBRANE MODELS IN A SPATIOTEMPORAL MANNER USING A DYNAMIC MOLECULAR INTERFACE. Adriana Kyvik, Barcelona, ES

10:15 - 10:35 ISOLATION OF ANTI-EXOSOME SINGLE DOMAIN ANTIBODIES BY DIRECT PANNING ON EXTRACELLULAR VESICLE ENRICHED FRACTIONS. Milica Popovic, Belgrade, RS

 

Poster presentations

POSTER 1

AFFINITY PROTEIN PURIFICATION RESULTING IN PROTEIN SEQUENCE WITHOUT REMAINING AMINO ACID RESIDUES

Heba Abd Elhameed, Balint Hajdu, Zita Fabian, Eniko Hermann, Wojtek Bal, Bela Gyurcsik

POSTER 2

Revealing dynamic alpha-helical polymers of Kfr_R751 plasmidic protein and mapping of its DNA- binding domain via biophysical measurements

Magdalena Kołodziejczyk, Roza Szatkowska, Tomasz Kobiela, Hanna Nieznańska, Malgorzata Adamczyk

 

POSTER 3

Antonio Alcaraz, Maria Queralt-Martin, Vicente M. Aguilella

POSTER 4

ANALYSIS OF ANCHOR MOLECULES FOR TETHERED BILAYER LIPID MEMBRANE FORMATION ON NOVEL SERS ACTIVE BIOSENSOR

Indre Aleknaviciene, Gintaras Valincius

 

POSTER 5

Impact of membrane lipid composition on Dopamine D2 receptor activation.

Isabel D. Alves, Véronique De Smedt-Peyrusse, Marie-Lise Jobin, Jonathan A. Javitch, Jean-Louis Banères, Thierry Durroux, Pierre Trifilieff

 

POSTER 6

DESIGN, IN VITRO TRANSCRIPTION, PURIFICATION AND CRYSTALLISATION OF RIBOSWITCHES

Blazej Baginski, Radosław Pluta, Agata Bernat and Janusz M. Bujnicki

 

POSTER 7

ROLE OF THE CYSTEINE-RICH REGION OF THE IRON-RESPONSIVE GATA FACTOR Fep1 IN [2Fe-2S] CLUSTER BINDING.

Antimo Cutone, Emilia Filardi, Adriana Miele^,, Giovanni Musci and Maria Carmela Bonaccorsi di Patti

 

POSTER 8

INTERACTION OF TETHERED BILAYER MEMBRANES WITH b-AMYLOID AND S100A9 AGGREGATES

Rima Budvytyte, Vytautas Smirnovas, Mathias Lösche and Gintaras Valincius

POSTER 9

REDOX SIGNALING : insights into the INTERACTION mechanism of SULFIREDOXIN WITH PEROXIREDOXIN and ATP

Florent Canonico, Audrey Beaussart, Alexandre Kriznik, Hortense Mazon, Sophie Rahuel-Clermont

 

POSTER 10

NON-CONTACT MECHANICAL AND CHEMICAL ANALYSIS OF SINGLE LIVING CELLS BY MICRO-SPECTROSCOPIC TECHNIQUES

Sara Mattana, Maurizio Mattarelli, Lorena Urbanelli, Krizia Sagini, Carla Emiliani^,, Mauro Dalla Serra, Daniele Fioretto^,, Silvia Caponi

 

POSTER 11

The pore architecture formed by two Cholesterol Dependent Cytolysins is tuned by the membrane lipid composition

Marta Marchioretto, Manuela Zanetti, Lorenzo Lunelli, Leon Juarez-Hernandez, Carlo Musio, Gregor Anderluh, Mauro Dalla Serra

 

POSTER 12

PROTEIN-PROTEIN AND PROTEIN-DNA INTERACTIONS BY SWITCHSENSE: COMPARISON WITH OTHER APPROACHES

Paloma Fernández Varela, Audrey Comte, Emeline Barbet-Massin, Jean-Baptiste Charbonnier

 

POSTER 13

INTRINSIC PROTEIN DISORDER COULD BE OVERLOOKED IN COCRYSTALLIZATION CONDITIONS: AN SRCD CASE STUDY

Béla Gyurcsik, Eszter Németh, Ria K. Balogh, Katalin Borsos, Anikó Czene, Peter W. Thulstrup

 

POSTER 14

CYTOCHROME C OXIDASE – A KEY COMPONENT OF THE OXIDATIVE PHOSPHORYLATION: REGULATION AND MODULATION OF ITS CATALYTIC ACTIVITY

Daniel Jancura, Marian Fabian

 

POSTER 15

MECHANISM OF MICROTUBULE PAIR SLIDING DRIVEN BY KINESIN-1

Beata Kliszcz, Michał Szkop, Karolina Podsiadło, Dorota Włoga, Andrzej A. Kasprzak

POSTER 16

Interactions of different Urolithins with Human Serum Albumin

Milica Kojadinovic, Aleksandra Arsic, Milica Popovic

POSTER 17

DURING ZEBRAFISH DEVELOPMENT WNT3 IS ASSOCIATED WITH LIPID RAFTS AS DEMONSTRATED BY SPIM-FCS

Xue Wen Ng, Cathleen Teh, Thorsten Wohland^,, Vladimir Korzh

 

POSTER 18

Using AFM to study erythrocytes’ morphology and elasticity on Amyotrophic Lateral Sclerosis

Catarina S. Lopes, Ana Catarina Pronto-Laborinho, Mamede de Carvalho^,, Nuno C. Santos, Filomena A. Carvalho

 

POSTER 19

Characterizing the interaction between Tau and microtubules using Site-Directed Spin labeling EPR spectroscopy

Marlène Martinho, Diane Allegro, Charlotte Chabaud, Emilien Etienne, Bruno Guigliarelli, Vincent Peyrot, Isabelle Landrieu, Pascale Barbier, Valérie Belle

 

POSTER 20

DATABASE OF CA PROTEIN-LIGAND BINDING GIBBS ENERGIES, ENTHALPIES, ENTROPIES, AND CRYSTAL STRUCTURES

Vaida Linkuvienė, Asta Zubrienė, Vaida Paketurytė, Alexey Smirnov, Vytautas Petrauskas, Daumantas Matulis

 

POSTER 21

TETHERED BILAYER LIPID MEMBRANES FOR PICOMOLAR DETECTION OF PORE-FORMING TOXINS

Tadas Penkauskas, Marija Jankunec, Gintaras Valincius

 

POSTER 22

BACK INTO A REAL MEDIUM: HOW A COMPLEX CROWDED AND CONFINING ENVIRONMENT MODULATES THE MOBILITY AND REACTIVITY OF BIOMOLECULES

Francesco Piazza, Josef Hamacek, Claire Perdrillat-Madeleine, Salvatore Magazù

 

POSTER 23

Regulation of the immune synapse and cytotoxic activity of natural killer (NK) cells by nanolithographic ligand patterning

Yossi Keydar^,, Guillaume Le Saux^,, Avishai Edri, Uzi Hadad, Angel Porgador, Mark Schvartzman

POSTER 24

HYDRODYNAMIC STUDY OF GOLD NANOPARTICLES CARRYING PROTEIN AND PEG-LIKE FILLER

Timothy Robson, Alexandra Solovyova and Jeremy H Lakey

 

POSTER 25

How SPR can be used to study Protein-DNA interactions in a multidisciplinary approach

Clare E. M. Stevenson, Aoun Assaad, Govind Chandra, Tung B. K. Le, Sandra J. Greive, Mervyn J. Bibb, Ngat T. Tran, Nicolle F. Som, Anyarat Thanapipatsiri, Adam S. B. Jalal, Tung B. K. Le and David M. Lawson

POSTER 26

PREPARATION AND CHARACTERIZATION OF SUPRAMOLECULAR SYSTEMS BASED ON AMPHIPHILIC β-CYCLODEXTRIN VESICLES AND LIPOSOMES FUNCTIONALIZED WITH ADAMANTYL GUANIDINES FOR GENE DELIVERY

Štimac, M. Tokić, A. Ljubetič, T. Vuletić, L. Frkanec, M. Šekutor and R. Frkanec

 

POSTER 27

Modification of Magnetic Nanoparticles with DNA Particulates and Their Applications in Magnetic Hyperthermia

Cem L. Altan, Seyda Bucak, Mehmet H. Ucisik, S. Sibel Erdem

 

POSTER 28

MG2+ BINDING TO RNA — A CRYSTALLOGRAPHIC PERSPECTIVE

Pascal Auffinger